PRP and hyaluronic acid for scars

Platelet-rich plasma (PRP) and non-cross-linked hyaluronic acid can be injected into scars after fractional CO2 laser to support healing and improve the skin. PRP supplies growth factors from the patient's own blood; hyaluronic acid hydrates the skin and has anti-inflammatory effects. Two randomised trials by Professor Nilforoushzadeh's group tested them alone and together.

What did the burn scar trial find?

In a 2024 randomised controlled trial, 10 people with burn scars had fractional CO2 laser followed by injections of PRP, hyaluronic acid, both, or a placebo, in two sessions a month apart, with follow-up at three months.

• Skin measurements, including hydration, water loss, redness, pigment, elasticity, thickness and density, improved significantly in the treatment groups compared with placebo.
• The Vancouver Scar Scale, a standard scar score, decreased in all treatment groups but not in the placebo group.
• Dermal thickness did not change significantly.

The authors conclude that PRP, hyaluronic acid and especially their combination are very effective for burn scars. With 10 participants, the trial is small.

What did the acne scar trial find?

A 2026 double-blind split-face trial treated 15 people with atrophic acne scars. One side of the face received PRP with hyaluronic acid; the other received PRP alone, hyaluronic acid alone or saline. Both patients and physicians were more satisfied with the combination, and the authors call for further studies to confirm the results. Fibroblast therapy, another option for acne scars, is covered in acne scar treatment with fibroblasts and PRP.

Why combine them with laser?

Fractional CO2 laser makes tiny controlled channels in the skin that trigger remodelling. Injecting regenerative products in the same session is meant to support that repair. The right combination depends on the scar and the skin, which is why it is planned with a dermatologist. For the wider picture, see the regenerative dermatology guide.